Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: ( A ) FDA-approved Dexcom G4 Platinum sensor for continuous glucose monitoring. The free tip was an 0.12 mm diameter platinum electrode (Glucose sensor) for sensing glucose after subcutaneous implantation and the other end was connected to a transmitter placed on the skin surface. The inserts show a sensor delivery syringe loaded with one glucose sensor ready for subcutaneous implantation and a signal transmitter. ( B ) Implantable HD-XG telemetry device for continuous monitoring of glucose, temperature, and locomotor activity. ( C ) Significant correlation between the glucose levels measured by Dexcom G4 Platinum and glucometer. ( D ) Significant correlation between the blood glucose levels measured by HD-XG telemetry device and glucometer.

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques: Activity Assay

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: Characteristics of the cynomolgus monkeys enrolled in the experiment.

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: Representative traces collected continuously from one conscious monkey implanted with a Dexcom G4 Platinum and another monkey with a HD-XG device. Panel A The marker on the top showed the day time (open bar) and night time (filled bar). Calibrations (Spots in red) were conducted twice per day during the period of glucose continuous monitoring. More variabilities of glucose levels occurred during the 2 nd day resulted from experimental procedures and feeding. Panel B From top to bottom: body temperature (1 st trace) with the marker on top to indicate day time (open bar) and night time (filled bar), physical activity (2 nd trace), blood glucose electrical signal (3 rd trace), and blood glucose level (4 th trace) after calculation from the corresponding glucose electrical signal. One ivGTT was conducted in the monkey during the 1 st day monitoring (see the arrows).

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques: Marker, Activity Assay

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: Oral glucose tolerance test (oGTT) was performed in the conscious normoglycemic (Panel A, n = 5 and B, n = 3) and hyperglycemic (Panel C, n = 5 and D, n = 2) monkeys. The glucose levels during glucose gavage oGTT were continuously monitored by the subcutaneously implanted Dexcom G4 platinum devices (tissue glucose, Panel A and C) or by the arterially implanted HD-XG devices (blood glucose, Panels B and D) and also by the glucometer simultaneously (blood glucose, Panel A,B,C and D).

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: Intravenous glucose tolerance test (ivGTT) was performed in the conscious normoglycemic (Panel A, n = 5 and B, n = 3) and hyperglycemic (Panel C, n = 5 and D, n = 2) monkeys. The glucose levels were continuously monitored by the subcutaneously implanted Dexcom G4 platinum devices (interstatial glucose, Panel A and C) or by the arterially implanted HD-XG devices (blood glucose, Panel B and D) and also by the glucometer simultaneously (blood glucose, Panel A,B,C and D).

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: The tissue glucose changes during glucose-gavage oGTT and banana-glucose feed oGTT in the conscious normoglycemic (Panel A, n = 5) and hyperglycemic (Panel B, n = 5) monkeys. The interstitial glucose levels were continuously monitored by the implanted Dexcom G4 platinum devices. Panel C, The blood glucose changes measured by the glucometer during banana-glucose feed oGTT and glucose gavage oGTT in the conscious hyperglycemic monkeys (n = 24).

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques:

Journal: Scientific Reports

Article Title: Comparison of Continuous Glucose Monitoring between Dexcom G4 Platinum and HD-XG Systems in Nonhuman Primates ( Macaca Fascicularis )

doi: 10.1038/s41598-017-09806-w

Figure Lengend Snippet: General characteristics of two continuous glucose monitoring systems.

Article Snippet: Compared with the glucometer blood glucose readings, the peak of the tissue glucose measured by the implanted Dexcom G4 Platinum devices was markedly delayed and reduced during ivGTT in both normoglycemic and diabetic monkeys (Fig. ).

Techniques: Sampling